Drugs used in Myasthenia Gravis

Table of Contents

Myasthenia Gravis

It is an autoimmune disorder affecting about 1 in 10,000 population, due to development of antibodies directed to the nicotinic receptors (NR) at the muscle endplate.
The number of free Nm cholinoceptors may be reduced to 1/3 of normal or less and structural damage to the neuromuscular junction.
It is an auto-immune disorder in which our immune system produce antibioties that block or destroy muscle’s receptor.
Break down in communication between nerves and muscles.

It is an auto-immune disorder. In this disorder our immune system produce antibodies to block/ destroy the Nicotinic receptor.
Because according to immune system these receptor are harmful for body. So these receptor and block them.
Now due to blockage of receptor acetycholine (Ach) does not bind on receptor.
Due to this there are loss of communication between nerves (Ach) and muscle.
Which further decrese the contraction of muscles.
Also muscle become weak and fatigue. These antibodies also destroy or kill the receptor. Due to this there are also decrease in the no. of receptors.

1. Cholinesterase Inhibitors:

Pyridostigmine: This is the most commonly used cholinesterase inhibitor. It works by inhibiting the breakdown of acetylcholine, thereby increasing its availability at the neuromuscular junction and improving muscle strength.
Pyridostigmine is usually administered orally and may be adjusted based on individual response and tolerance.

2. Neostigmine:

Neostigmine is a cholinesterase inhibitor, prescribed for Myasthenia Gravis.
It inhibits the chemicals, which brings non-communication between the nervous and the muscular system. Neostigmine enhances the muscular movements in case of Myasthenia Gravis condition.

3. Immunosuppressant: